{"id":3552,"date":"2026-11-04T15:24:33","date_gmt":"2026-11-04T15:24:33","guid":{"rendered":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/?p=3552"},"modified":"2026-11-04T15:24:33","modified_gmt":"2026-11-04T15:24:33","slug":"new-study-shows-promise-for-advanced-melanoma-treatment-using-gut-bacteria","status":"publish","type":"post","link":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/new-study-shows-promise-for-advanced-melanoma-treatment-using-gut-bacteria\/","title":{"rendered":"New Study Shows Promise for Advanced Melanoma Treatment Using Gut Bacteria"},"content":{"rendered":"

A clinical trial called MELODY-1 has shown encouraging results for patients with advanced melanoma that did not respond to standard immunotherapy. The study tested a new treatment called MB097, which contains a mix of nine specific bacteria<\/a> taken by mouth. This treatment is designed to change the balance of bacteria in the gut, which may help the body respond better to a cancer<\/a> drug called pembrolizumab (also known as KEYTRUDA).<\/p>\n

The trial included 41 patients whose melanoma had stopped responding to anti-PD-1 therapy, a common type of immunotherapy. These patients had already tried multiple treatments without success. The participants were split into two groups: one group received a short course of an antibiotic called vancomycin before starting MB097, while the other group did not. After 24 weeks of treatment with MB097 plus pembrolizumab, the researchers found that three out of 21 patients in the vancomycin group had a significant reduction in their tumors, including one patient who experienced complete remission. In the group without vancomycin, two out of 20 patients had a positive response.<\/p>\n

The treatment was safe, with no serious side effects linked to MB097. The bacterial mix in MB097 was able to establish itself well in the gut, especially in patients who took vancomycin beforehand. Experts believe these findings support the idea that gut bacteria may play a role in helping immunotherapy work better for cancer patients. The researchers plan to continue studying this approach in larger trials to confirm these early results.<\/p>\n","protected":false},"excerpt":{"rendered":"

A clinical trial called MELODY-1 has shown encouraging results for patients with advanced melanoma that did not respond to standard […]<\/p>\n","protected":false},"author":0,"featured_media":3553,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[543],"tags":[],"class_list":["post-3552","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pharmaceutical-news"],"_links":{"self":[{"href":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/wp-json\/wp\/v2\/posts\/3552","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/wp-json\/wp\/v2\/comments?post=3552"}],"version-history":[{"count":1,"href":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/wp-json\/wp\/v2\/posts\/3552\/revisions"}],"predecessor-version":[{"id":3559,"href":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/wp-json\/wp\/v2\/posts\/3552\/revisions\/3559"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/wp-json\/wp\/v2\/media\/3553"}],"wp:attachment":[{"href":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/wp-json\/wp\/v2\/media?parent=3552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/wp-json\/wp\/v2\/categories?post=3552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/allesleypharmacy.co.uk\/pharmacy\/wp-json\/wp\/v2\/tags?post=3552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}